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Green solid-phase peptide synthesis 4. γ-Valerolactone and N-formylmorpholine as green solvents for solid phase peptide synthesis |
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| Authors: | Ashish Kumar Yahya E Jad Ayman El-Faham Beatriz G de la Torre Fernando Albericio |
| Institution: | 1. School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa;2. School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa;3. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;4. Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, 12321 Alexandria, Egypt;5. School of Laboratory of Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4001, South Africa;6. Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain;7. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Barcelona 08028, Spain |
| Abstract: | Herein, we report the use of γ-valerolactone (GVL) and N-formylmorpholine (NFM) as DMF substitutes in polystyrene based SPPS. The solubility of selected amino acids and coupling reagents were studied in GVL and NFM, followed by their use in the successful synthesis of Aib-enkephalin pentapeptide (H-Tyr-Aib-Aib-Phe-Leu-NH2) and Aib-ACP decapeptide (H-Val-Gln-Aib-Aib-Ile-Asp-Tyr-Ile-Asn-Gly-NH2). |
| Keywords: | Solid-phase peptide synthesis Green solvents Polystyrene resin GVL NFM |
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