Asymmetric one-pot synthesis of five- and six-membered lactones via dynamic covalent kinetic resolution: Exploring the regio- and stereoselectivities of lipase |
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| Authors: | Jintao Xu Lei Hu |
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| Institution: | School of Pharmacy, Jiangsu University, Zhenjiang 212013, China |
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| Abstract: | Cascade lipase-catalyzed lactonization has been applied to dynamic hemithioacetal formation, leading to efficient five- and six-membered lactone synthesis as well as chiral discrimination. Solvent-dependent regioselectivity was observed for the selective formation of 1,3-oxathiolan-5-one and γ-butyrolactone derivatives. |
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| Keywords: | Dynamic kinetic resolution Enzymatic catalysis Heterocycle Solvent effect |
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