Synthesis of β,β-branched β-amino ester derivatives through spiroaziridination of (α-trimethylsilanylmethyl)cyclohexylidene esters |
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| Authors: | Tecla Gasperi MAntonietta Loreto PAntonio Tardella |
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| Institution: | a Dipartimento di Chimica, Università ‘La Sapienza’, P. le Aldo Moro 5, I-00185 Rome, Italy
b Istituto C.N.R. di Chimica Biomolecolare-Sezione Roma, Dipartimento di Chimica, Università ‘La Sapienza’, P. le Aldo Moro 5, I-00185 Rome, Italy |
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| Abstract: | The reaction of (α-trimethylsilanylmethyl)cyclohexylidene esters with NsONHCO2Et and CaO produces the N-(ethoxycarbonyl)spiroaziridines which, after ring-opening, gives the corresponding β,β-disubstituted β-amino ester derivatives. The stereochemical outcome of the reaction is influenced by substituents on the cyclohexyl group. |
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| Keywords: | β-amino esters aziridines allysilanes |
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