Enhanced selectivity in Novozym 435 catalyzed kinetic resolution of secondary alcohols and butanoates caused by the (R)-alcohols |
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| Authors: | Elisabeth Egholm JacobsenErik van Hellemond Anders Riise MoenLucia Camino Vazquez Prado Thorleif Anthonsen |
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| Institution: | Department of Chemistry, Norwegian University of Science and Technology, N-7491 Trondheim, Norway |
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| Abstract: | In esterifications of secondary alcohols catalyzed by immobilized lipase B from Candida antarctica (Novozym 435) the E-values decreased during the reaction. Hydrolysis of the corresponding butanoates showed the opposite effect. When an enantiopure (R)-alcohol, related but different, was added to the transesterification reaction, the E-value was significantly enhanced. |
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