An expedient one-pot entry to catecholestrogens and other catechol compounds via IBX-mediated phenolic oxygenation |
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| Authors: | Alessandro Pezzella Liliana Lista Alessandra Napolitano Marco d’Ischia |
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| Institution: | Department of Organic Chemistry and Biochemistry, University of Naples ‘Federico II’, Via Cinthia 4, I-80126, Naples, Italy |
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| Abstract: | A one-pot procedure for the preparation of catecholestrogens in over 90% yield is reported, involving oxygenation of 17β-estradiol or estrone with o-iodoxybenzoic acid (IBX) followed by reduction with methanolic NaBH4. The procedure, which was extended to the o-hydroxylation of a number of representative phenols in good-to-high yields, expands significantly the scope of phenolic oxidation mediated by IBX. |
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| Keywords: | Estrogens IBX Catechols |
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