Hydrolysis rates of alkyl and aryl sulfinamides: evidence of general acid catalysis |
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Authors: | Andrew M Piggott |
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Institution: | Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia |
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Abstract: | Sulfinamides are important in enantioselective synthesis, as rare post-translational modifications of proteins and as isosteres of the amide bond. Little is known about the rates of hydrolysis for aliphatic sulfinamides or the mechanism of hydrolysis. In this Letter, we show that sulfinamides hydrolyse by predominantly a non-specific acid/base catalysis with phosphate buffer but by varying the buffer concentration, it was possible to determine the hydrolysis rates of a range of sulfinamides with water through non-linear least squares regression. |
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Keywords: | Sulfinamide Hydrolysis Non-specific acid/base catalysis Enzyme inhibitors |
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