NIS-promoted guanylation of amines |
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| Authors: | Keiichiro Ohara Michael Smietana |
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| Institution: | Institut des Biomolécules Max Mousseron, UMR 5247 CNRS Université Montpellier 1, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier, France |
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| Abstract: | An efficient NIS-promoted guanylation reaction is described. This procedure allows the guanylation of primary and secondary amines through the reaction with di-Boc-thiourea and di-Boc-S-methylisothiourea, respectively. We demonstrated that the use of NIS compares favorably with existing methods and is an attractive alternative to heavy metal or Mukayama’s reagent activation. |
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| Keywords: | NIS Guanidine Thiourea derivatives |
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