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Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate |
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| Authors: | Odile Meyer |
| Institution: | Université Louis Pasteur - CNRS (UMR 7177 LC3), Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France |
| Abstract: | An improved synthesis of 1,1,1-trifluoro-1-deoxy-d-xylulose 5-phosphate and an access to the reduced diastereomer mixture analogues 1,1,1-trifluoro-1-deoxy-d-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-d-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated. |
| Keywords: | d-xylulose 5-phosphate reductoisomerase" target="_blank">1-Deoxy-d-xylulose 5-phosphate reductoisomerase Isoprenoid biosynthesis: 1 1 d-xylulose 5-phosphate" target="_blank">1-trifluoro-1-deoxy-d-xylulose 5-phosphate |
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