Ag2CO3-catalyzed cycloaddition of organic azides onto terminal alkynes: A green and sustainable protocol accelerated by aqueous micelles of CPyCl |
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| Authors: | Jasmin Sultana Nageshwar D Khupse Srijita Chakrabarti Pronobesh Chattopadhyay Diganta Sarma |
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| Institution: | 1. Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India;2. Center for Materials for Electronics Technology, Pashan Road, Pune 411008, India;3. Defence Research Laboratory, Tezpur 784001, Assam, India |
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| Abstract: | Using catalytic amount of Ag2CO3 a simple, efficient and copper free green protocol has been developed to synthesize 1,4-disubstituted 1,2,3-triazoles regioselectively. Here, the cationic surfactant, cetylpyridinium chloride (CPyCl) in water provides a micellar media and accelerates the subsequent Ag(I)-catalysed azide-alkyne cycloaddition (AgAAC) reaction by increasing the concentration of reactants in the micellar pseudophase. Our method is found to be environmentally friendly from E-factor measurement. The surfactant, CPyCl is found to be nontoxic. |
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| Keywords: | AgAAC CPyCl Non-toxic surfactant Negligible E-factor |
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