Tf-based sulfamide-amine alcohol-catalyzed enantioselective alkynylation of aldehydes |
| |
Authors: | Hongwang Li |
| |
Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China |
| |
Abstract: | A series of new chiral Tf-based sulfamide-amine alcohols (Tf-based SAA) were synthesized from natural chiral (−)-ephedrine and aziridines derived from commercially available chiral amino alcohols. Among these ligands, 3a was found to be more effective for the addition reaction of alkynylzinc to aromatic aldehyes at room temperature without using other kinds of metal species, providing 81-92% ee and up to 99% yields. |
| |
Keywords: | Sulfamide-amine alcohols Asymmetric addition Propargylic alcohols Alkynylation Aldehydes |
本文献已被 ScienceDirect 等数据库收录! |