Efficient synthesis and antioxidant activity of coelenterazine analogues |
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| Authors: | Yueting Lu Rudi HendraAaron J Oakley Paul A Keller |
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| Institution: | School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia |
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| Abstract: | A convenient and highly convergent method for the synthesis of new imidazo1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH). |
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| Keywords: | Coelenterazine Imidazo[1 2-a]pyridine Benzylglyoxals Antioxidant 2 2-Diphenyl-1-picrylhydrazyl |
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