One-pot synthesis of tryptanthrin by the Dakin oxidation of indole-3-carbaldehyde |
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| Authors: | Takumi Abe Tomoki Itoh Tominari Choshi Satoshi Hibino Minoru Ishikura |
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| Institution: | 1. School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan;2. Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan |
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| Abstract: | A one-pot approach to indolo2,1-b]quinazolines from indole-3-carbaldehydes through the Dakin oxidation was developed. It was shown that the reaction proceeded through the condensation of indole-3-carbaldehydes with isatoic anhydrides, derived in situ from indole-3-carbaldehydes by the Dakin oxidation, and further oxidation/cyclization steps. |
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| Keywords: | Oxidative coupling Indole-3-carbaldehyde Indolo[2 1-b]quinazoline Urea hydrogen peroxide Dakin oxidation |
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