l-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2]cycloaddition of azide |
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Authors: | Narsimha Reddy Penthala Nikhil Reddy MadadiVenumadhav Janganati Peter A Crooks |
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Institution: | Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA |
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Abstract: | Use of a novel reagent has been established for the synthesis of a series of 4,5-diaryl-2H-1,2,3-triazoles (6a–i and 9a–e) from cyanostilbene analogs of benzob]thiophene, benzob]furan, and indole, catalyzed by l-proline via Lewis base-catalyzed one-step 3+2]cycloaddition of azide. This method provides an efficient, simple, and environmentally benign procedure that affords good yields and relatively short reaction times. |
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Keywords: | 4 5-Diaryl-2H-1 2 3-triazoles l-Proline Heteroaryl cyanostilbenes Sodium azide [3+2]Cycloaddition of azide |
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