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Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida |
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| Authors: | Dong-Bao Hu Wen-Xin Li Zhen-Zhu Zhao Tao Feng Rong-Hua Yin Zheng-Hui Li Ji-Kai Liu Hua-Jie Zhu |
| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. Chinese Center for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Ministry of Education, College of Pharmacy, Hebei University, Baoding 071002, People’s Republic of China;3. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China |
| Abstract: | Four new highly unsaturated pyranone derivatives A–D (1–4), together with one known compound 5 (−)-nitidon were isolated from cultures of the fungus Junghuhnianitida. Planar structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. Absolute configurations of the new compounds were determined on the basis of biosynthetic considerations and quantum chemistry theory. Compound 1 exhibited almost the same cytotoxic activities as cis-platin. |
| Keywords: | Antitumour agents Junghuhnianitida derivatives Absolute configuration determination DFT Matrix |
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