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Peculiar side-chain fission of steroidal glycosides |
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| Authors: | Alaa Mohamed NafadyMohamed Ahmed El-Shanawany Mahmoud Hamed MohamedHashim Abdel-Halim Hassanean Xing-Hua ZhuTsutomu Yoshihara Masafumi OkawaTsuyoshi Ikeda Toshihiro Nohara |
| Institution: | a Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan b Faculty of Pharmacy, Assiut University, Assiut, Egypt c Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt |
| Abstract: | The characteristic novel steroidal glycosides of the 23,26-oxygenated spirostanol-type and 16,22-dicarbonyl cholestanol-type obtained in our laboratory underwent the peculiar reactions of side-chain fission between C-22 and C-23 of the steroidal skeleton by acid or alkaline hydrolysis. These reactions would be applied to the structural determination of these sorts of glycosides and suggest the biogenetic pathway of the occurrence of C-22 lactone-type glycosides. |
| Keywords: | steroidal glycoside 23 26-oxygenated spirostanol 16 22-dicarbonyl cholestanol side-chain fission |
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