Efficient one-pot preparation of 5-substituted-2-amino-1,3,4-oxadiazoles using resin-bound reagents |
| |
Authors: | Frank T Coppo Todd L Graybill George Burton |
| |
Institution: | GlaxoSmithKline Pharmaceuticals, Discovery Research, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA |
| |
Abstract: | A robust one-pot solution-phase synthesis of 2-amino-1,3,4-oxadiazoles directly from acylhydrazines and isothiocyanates is described. Commercially-available polymer-supported reagents help facilitate both cyclization and purification. This convenient method benefits from its broad applicability, ease and safety of reagent handling, simple product isolation, and the ability to perform multiple reactions in parallel fashion without need for purification. The details and scope of this reaction strategy are presented herein. |
| |
Keywords: | Oxadiazole 2-Amino-1 3 4-oxadiazole 1 3 4-Oxadiazole Carbodiimide Acylhydrazine Acylthiosemicarbazide Parallel synthesis Solid-supported reagents |
本文献已被 ScienceDirect 等数据库收录! |
|