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Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN and stoichiometric amount of HCN |
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| Authors: | Nobuki Kato Masato Suzuki Masakatsu Shibasaki |
| Institution: | a Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan b PRESTO, Japan Science and Technology Corporation, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
| Abstract: | Catalyst loading as low as 0.1 mol % was achieved in the enantioselective Strecker reaction of ketoimines. Excellent enantioselectivity was obtained with a combined use of a catalytic amount of TMSCN and a stoichiometric amount of HCN as a reagent, and a chiral gadolinium complex as a catalyst. |
| Keywords: | Asymmetric catalysis Strecker reaction Ketoimines Disubstituted amino acids Atom economy |
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