A novel and efficient method for inside selective esterification of terminal vic-diols |
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| Authors: | Masahiro Ikejiri |
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| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan |
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| Abstract: | A novel and highly efficient procedure for inside selective esterification of terminal vic-diols has been achieved in one-pot via Yb(OTf)3-catalyzed formation and partial hydrolysis of cyclic orthoesters. This method offers several advantages including wide compatibility with acid labile functional groups, and good to high regioselectivity and yields. |
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| Keywords: | Esterification Regioselectivity Lanthanide triflate Orthoester |
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