Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix |
| |
| Authors: | Takanori MiyashitaNoritake Matsumoto Tomohisa MoriguchiKazuo Shinozuka |
| |
| Institution: | a Chemistry Lab., Yamasa Corporation, 2-10-1 Araoicho, Choshi 288-0056, Japan
b Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu 376-8515, Japan |
| |
| Abstract: | A novel phosphoramidite synthon of a dinucleoside phosphotriester unit bearing an intercalative moiety at its internucleotide linkage in a stereospecific manner was prepared and successfully incorporated into the middle portion of α-β chimeric oligoDNA. One of the resulting stereoisomeric chimera DNAs strongly enhances the thermal stability of an alternate-stranded triplex formed between the chimera and a double-stranded DNA. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
