Aromatic polyketide glycosides from an entomopathogenic fungus,Cordyceps indigotica |
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Authors: | Teigo Asai Takashi Yamamoto Yu-Ming Chung Fang-Rong Chang Yang-Chang Wu Kouwa Yamashita Yoshiteru Oshima |
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Institution: | 1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan;2. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;3. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan;4. Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
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Abstract: | A new aromatic polyketide glycoside, indigotide A (1), was isolated from the culture broth of the entomopathogenic fungus, Cordyceps indigotica, along with known cyclic depsipeptides, destruxins A, A2, B, B2 and E (3–7), and a polyketide, NG-393 (8). Repeated treatment of the C. indigotica culture broth with 5-azacytidine, a DNA methyltransferase inhibitor, led to the isolation of another new aromatic polyketide glycoside, indigotide B (2). |
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