Synthesis and use of chiral substituted benzenes containing 1,2-diols protected as cyclic acetals |
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Authors: | Chandrashekar Ramarao Ramadevi Nandipati Rajasekhar Navakoti Ramanjaneyulu Kottamasu |
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Institution: | Avra Laboratories Pvt. Ltd, Avra House, 54 Sai Enclave, Habsiguda, Hyderabad 500007, India |
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Abstract: | 1,2-Dihydroxy benzenes have been protected as cyclic diacetals using 2,3-butane dione. These diacetals are extremely robust and can be further chemically diversified and resolved with chirality embedded in the 1,4-dioxane ring attached to the aromatic back bone as a result of the anomeric effect. These systems can serve as ligands, auxiliaries or organocatalysts for asymmetric synthesis. |
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