Towards CRISPR powered electrochemical sensing for smart diagnostics |
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| Authors: | Poyye Dsouza Priya Swetha Jospeh Sonia Kannan Sapna K Sudhakara Prasad |
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| Institution: | 1. Nanomaterial Research Laboratory (NMRL), Nano Division, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, 575 018, India;2. Centre for Nutrition Studies, Yenepoya (Deemed to be University), Deralakatte, Mangalore, 575 018, India |
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| Abstract: | Even though global health has been steadily improved, the global disease burden associated with communicable and non-communicable diseases extensively increased healthcare expenditure. The present COVID-19 pandemic scenario has again ascertained the importance of clinical diagnostics as a basis to make life-saving decisions. In this context, there is a need for developing next-generation integrated smart real-time responsive biosensors with high selectivity and sensitivity. The emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas biosensing systems has shown remarkable potential for developing next-generation biosensors. CRISPR/Cas integrated electrochemical biosensors (E-CRISPR) stands out with excellent properties. In this opinionated review, we illustrate the rapidly evolving applications for E-CRISPR-integrated detection systems towards biosensing and the future scope associated with E-CRISPR based diagnostics. |
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| Keywords: | CRISPR/Cas Electrochemical Biosensing Point-of-care E-CRISPR |
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