Recent advances of scanning electrochemical microscopy and scanning ion conductance microscopy for single-cell analysis |
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| Authors: | Junjie Zhang Tong Zhu Jinxin Lang Wenxuan Fu Fei Li |
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| Institution: | 1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi''an Jiaotong University, Xi''an, 710049, PR China;2. Bioinspired Engineering and Biomechanics Center (BEBC), Xi''an Jiaotong University, Xi''an, 710049, PR China;3. Department of Cardiovasology, Xidian Group Hospital, Shaanxi Province, Xi''an, 710077, PR China |
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| Abstract: | Single-cell analysis is important for understanding fundamental biological processes and mechanisms. Scanning electrochemical microscopy and scanning ion conductance microscopy as two kinds of scanning probe microscopy, with high temporal and spatial resolutions as well as in situ and noninvasive characterization capabilities, emerge as strong tools for single-cell analysis. In this review, we introduce the latest advances of scanning electrochemical microscopy and scanning ion conductance microscopy for single-cell analysis, including characterizations of cell morphology dynamics, membrane properties and mechanics, and monitoring cell surface charge, extracellular pH, and intracellular substances. |
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| Keywords: | Single-cell analysis SECM SICM |
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