Interaction of <Emphasis Type="Italic">E. coli</Emphasis> DNA with diazine-bridged late first row transition metal complexes derived from hexadentate compartmental ligands: an approach to DNA cleavage/binding studies |
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Authors: | Srinivasa Budagumpi Vidyanand K Revankar |
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Institution: | (1) Department of Chemistry, Karnatak University, Dharwad, Karnataka, 580 003, India; |
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Abstract: | A series of binuclear CoII, NiII, CuII and ZnII complexes having μ-1,2 diazine bridging have been prepared and characterized by various physico-chemical methods. The hexadentate
ligands were synthesized by condensing 3,5-dichloroformyl-1H-pyrazole with 2-hydrazinobenzothiazole (L1H) or 4-aminoantipyrine (L2H) in 1:2 ratio. Gel electrophoresis data indicate cleavage of E. coli DNA to a minute extent by both Co2L2(μ-Cl)Cl2(H2O)2]·H2O and Ni2L2(μ-Cl)Cl2(H2O)2]. Conversely, the data for the remaining complexes indicated binding but not cleavage. These results were confirmed by viscosity
measurements and absorption spectral studies. An intercalative binding mode is predicted when the title complexes interact
with DNA. |
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