Synthesis,characterization, and urease inhibitory activity of two copper(II) complexes of cyclohexanecarboxylate |
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| Authors: | Lei Sun Yuguang Li Xiongwei Dong Mingxia Guo |
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| Institution: | (1) School of Chemistry and Chemical Engineering, Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan, 430073, People’s Republic of China; |
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| Abstract: | The crystal structures of two copper(II) complexes of the cyclohexanecarboxylate ligand, namely Cu(C6H11CO2)2(H2O)2]·H2O (1) and Cu(dpyam)2(C6H11CO2)](NO3)·H2O (2) (C6H11CO2H = cyclohexanecarboxylic acid; dpyam = di-2-pyridylamine), have been determined by single-crystal X-ray analysis. Complex
1 contains the square-planar trans-CuO4 chromophore, while 2 shows the square pyramidal cis-distorted octahedral CuN4OO′ chromophore. Both complexes were found to show strong inhibitory activity against jack bean urease (IC50 = 1.75 and 8.57 μM for 1 and 2, respectively), when compared with acetohydroxamic acid (IC50 = 63.12 μM). |
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