Synthesis,characterization and antitumor activity of palladium(II) complexes of imidazolidine-2-thione |
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| Authors: | Thales R de Moura Sahra L Cavalcanti Paulo R D V de Godoy Elza T Sakamoto-Hojo Fillipe V Rocha Eduardo T de Almeida Victor M Deflon Antonio E Mauro Adelino V G Netto |
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| Institution: | 1.Departamento de Química Geral e Inorganica, Instituto de Química de Araraquara,UNESP – Univ Estadual Paulista,Araraquara,Brazil;2.Departamento de Biologia,Faculdade de Filosofia, Ciências e Letras de Ribeir?o Preto,Ribeir?o Prêto,Brazil;3.Departamento de Química,Universidade Federal de S?o Carlos,S?o Carlos,Brazil;4.Instituto de Química,UNIFAL - MG - Univ Federal de Alfenas,Alfenas,Brazil;5.Instituto de Química de S?o Carlos,Universidade de S?o Paulo,S?o Carlos,Brazil |
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| Abstract: | Complexes of the type cis-PdX2(imzt)(PPh3)] {imzt = imidazolidine-2-thione; PPh3 = triphenylphosphine; X = Cl (1), Br (2), I (3), SCN (4)} have been synthesized and characterized by elemental analyses, molar conductance, IR and 1H NMR spectroscopies. The complex 1·MeOH was obtained from the reaction of PdCl2(CH3CN)2], imidazolidine-2-thione and triphenylphosphine in CHCl3/CH3OH. Complexes 2·MeOH, 3 and 4 were prepared by metathesis of the chlorido ligands in 1 with bromide, iodide and thiocyanate, respectively. Elemental analyses showed good agreement with the expected mononuclear compositions, while the molar conductivities of the complexes in DMF were consistent with their nonelectrolytic nature. NMR spectra confirmed coordination of the imidazolidine-2-thione and triphenylphosphine ligands. Single-crystal X-ray diffraction determination of 1·CH3OH showed that the coordination geometry around PdII is nearly square planar, with the chlorido ligands in a cis configuration. All four complexes have been tested in vitro by XTT assay for their cytotoxicity against human glioblastoma cell line (U87MG). The binding of 1 with guanosine was studied by 1H NMR spectroscopy, revealing that the coordination takes place via N7. |
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