Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands |
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| Authors: | Elvan Üstün Aykut Özgür Kübra A Coşkun Serpil Demir Düşünceli İsmail Özdemir Yusuf Tutar |
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| Institution: | 1.Department of Chemistry, Faculty of Art and Science,Ordu University,Ordu,Turkey;2.Department of Bioengineering, Faculty of Natural Sciences and Engineering,Gaziosmanpa?a University,Tokat,Turkey;3.Department of Chemistry, Faculty of Science,?n?nü University,Malatya,Turkey;4.Division of Biochemistry, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy,Cumhuriyet University,Sivas,Turkey |
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| Abstract: | Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer. |
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