Cytotoxic and DNA-binding properties of two ruthenium(II) porphyrin complexes |
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Authors: | Wen-Jie Mei Xin-Yu Wei Wen-Na Li Qiang Xia |
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Institution: | (1) School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China;(2) Department of Pharmacology, Zhuhai Campus of Zunyi Medical College, Zhuhai, 519041, People’s Republic of China |
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Abstract: | Two ruthenium(II) porphyrin complexes Ru(L)2Cl(PTP)]+ (L = bpy, 1, phen; 2; PTP = 5-(3′-pyridyl)-10,15,20-trimethylphenylporphyrin) have been synthesized and their antitumor activities have been evaluated
by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) methods. Both complexes exhibit high inhibitory activity
against the growth of human cervical carcinoma cell line HeLa, both with and without light treatment. However, when treated
with light, the inhibitory activity for both complexes increases at low drug concentration. Spectroscopic studies show that
both complexes can bind to HeLa DNA tightly with apparent binding constants of 1.54(±0.07) × 105 and 1.01(±0.02) × 105 M−1 for 1 and 2, respectively. |
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