Synthesis of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidines |
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| Authors: | Abolghasem Davoodnia Rahele Zhiani and Niloofar Tavakoli-Hoseini |
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| Institution: | (1) Center of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Ł?dz?, Sienkiewicza 112, Poland;(2) Department of Chemistry and Environment Protection, Jan Długosz University, Armii Krajowej 13/15, Cze˛stochowa, Poland;(3) Faculty of Bioscience Engineering, Department of Chemistry, Ghent University, Coupure links 653, 9000 Ghent, Belgium |
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| Abstract: | Starting from 1,5-dihydro-4H-pyrazolo3,4-d]pyrimidin-4-ones, a synthesis pathway to the tricyclic pyrazolo4,3-e]1,2,4]triazolo4,3-c]pyrimidines is described. Reaction of 1,5-dihydro-4H-pyrazolo3,4-d] pyrimidin-4-ones with phosphoryl chloride afforded the corresponding 4-chloro-1H-pyrazolo3,4-d]pyrimidines. Treatment of these compounds with hydrazine hydrate at reflux temperature gave the hydrazino derivatives, which
were subsequently cyclized to the titled compounds on heating with orthoesters in ethanol. |
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