An Efficient Method for the Synthesis of 3-Cyano-6-hydroxy-2(1H)-pyridinones under Microwave Irradiation and Solvent-free Conditions |
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| Authors: | Saeed Balalaie Elahe Kowsari Mehri S Hashtroudi |
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| Institution: | (1) Chemistry Department, K. N. Toosi University of Technology, P.O. Box 15875-4416 Tehran, Iran, IR;(2) Energy and Environment Department, Material and Energy Research Center, Tehran, Iran, IR |
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| Abstract: | Summary. Three component condensation of alkylacetoacetates, primary amines, and alkyl cyanoacetates catalyzed by solid supports under
microwave irradiation gave N-alkyl 3-cyano-6-hydroxy-2(1H)-pyridinones with high yields. Upon carrying out the reaction under the same condition on acidic alumina, zeolite HY, silica
gel, and montmorillonite K-10, the best yields were achieved by silica gel.
Corresponding author. E-mail: balalaie@yahoo.com
Received August 28, 2002; accepted September 3, 2002 |
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| Keywords: | , Solvent-free organic synthesis, Microwave chemistry, Cyclocondensation, 2-pyridinones, |
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