Diastereoselective Photochemical Synthesis of α-Amino-β-hydroxyketones by Photocycloaddition of Carbonyl Compounds to 2,5-Dimethyl-4-isobutyloxazole |
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Authors: | Samir Bondock Axel G Griesbeck |
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Institution: | Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt Institute of Organic Chemistry, University of Cologne, K?ln, Germany
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Abstract: | Summary. The photocycloaddition of aldehydes and α-ketoesters to 2,5-dimethyl-4-isobutyloxazole leads to bicyclic oxetanes with high
to moderate (exo) diastereoselectivity that can be easily ring-opened to give α-amino-β-hydroxyketones. |
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Keywords: | , Photocycloaddition, 2,5-Dimethyl-4-isobutyloxazole, Carbonyl compounds, Oxetanes, α,-Amino-β,-hydroxyketones, |
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