The Synthesis of D-Heteroannulated 3β-Hydroxy-13α-androst-5-ene Derivatives via α-Oxoketene Dithioacetal and α-Oxohydroxymethylidene Synthons |
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| Authors: | Ágota Szájli János Wölfling |
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| Institution: | (1) Department of Organic Chemistry, University of Szeged, Szeged, Hungary |
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| Abstract: | Summary. 16-Ketene dithioacetal derivatives of 3β-hydroxy-13α-androst-5-en-17-one react with amidine, benzamidine, or guanidine to
yield novel pyrimido-fused D-heteroannulated steroids. The reactions of 3β-hydroxy-16-hydroxymethylidene-13α-androst-5-en-17-one
with N,N′-dinucleophiles furnish heterocycles containing a pyrazole ring fused to positions 16,17 of the sterane skeleton. |
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| Keywords: | , Steroids, Heterocycles, Lewis acids, Pyrazolones, Pyrimidines, |
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