Synthesis of 5-Substituted 1,3-Dimethylpyrazolo[4,3-<Emphasis Type="Italic">e</Emphasis>][1,2,4]triazines |
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Authors: | Kayed A Abu Safieh Ahmad M Abu Mahthieh Mustafa M El-Abadelah Mikdad T Ayoub Wolfgang Voelter |
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Institution: | 1.Chemistry Department, Faculty of Science,The Hashemite University,Zarqa,Jordan;2.Chemistry Department, Faculty of Science,University of Jordan,Amman,Jordan;3.Interfakult?res Institut für Biochemie,Universit?t Tübingen,Tübingen,Germany |
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Abstract: | Summary. A novel method for the synthesis of a new series of 5-substituted 1,3-dimethyl pyrazolo4,3-e]1,2,4]triazines is described. The new synthetic strategy is based on the classical Bischler 1,2,4-benzotriazine synthesis. This approach involves the preparation of 5-hydrazinopyrazole from 5-chloro-1,3-dimethyl-4-nitropyrazole
followed by acylation and nitro group reduction to form the corresponding 4-amino-3-(acylhydrazino)pyrazoles. Intramolecular
oxidative cyclization of the latter derivatives, using polyphosphoric acid, produced the respective target pyrazolotriazines. |
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Keywords: | , Pyrazolotriazines, Bischler reaction, Oxidative cyclisation, |
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