SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols |
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| Authors: | Heinrich Berger Werner Seebacher Marcel Kaiser Reto Brun Robert Saf and Robert Weis |
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| Institution: | (1) Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Universit?tsplatz 1, 8010 Graz, Austria;(2) Swiss Tropical Institute, Basel, Switzerland;(3) Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria; |
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| Abstract: | Abstract Several 4-amino-6,7-diarylbicyclo2.2.2]octan-2-ols bearing varying substituents on the aromatic rings were synthesized following
a manual method for applying the Hansch approach. All new compounds were tested for their activity against the causative organisms
of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed. |
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