Synthesis of some pyridine, thiopyrimidine, and isoxazoline derivatives based on the pyrrole moiety |
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Authors: | Mohamed A A Radwan and Eman M H Abbas |
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Institution: | (1) Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt;(2) Department of Chemistry of Natural products, National Research Centre, Dokki, Cairo, Egypt |
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Abstract: | Abstract Condensation of 2-acetylpyrrole with 5-methylfuran-2-carboxyaldehyde and 4-chlorobenzaldehyde in 20% NaOH give the corresponding
2-chalconylpyrroles. Some new 2-alkoxy-3-cyano-4,6-diarylpyridines were synthesized by condensation of chalcones with malononitrile,
followed by cyclization in sodium alkoxide. The reactivity of chalcones towards nitrogen nucleophiles such as thiourea and
hydroxylamine hydrochloride to provide thiopyrimidines and isoxazolines was investigated. |
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