The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile |
| |
Authors: | Robert V Stick Andrew G Watts |
| |
Institution: | (1) Department of Chemistry, The University of Western Australia, Crawley WA, 6009 Australia, AU |
| |
Abstract: | Summary. This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl
transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable
procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the
study of the mechanism of action of retaining glycosyl transferases.
Received October 16, 2001. Accepted November 7, 2001 |
| |
Keywords: | , ,Glycoside hydrolases, Glycosyl transferases, 2-Deoxy-2-fluoro hexopyranoses, |
本文献已被 SpringerLink 等数据库收录! |
|