A Convenient Synthesis of NovelDerivatives of Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-5,6-dione |
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| Authors: | Mosselhi A N Mosselhi |
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| Institution: | (1) Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt, EG |
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| Abstract: | Summary. Reaction of 6-Amino-2-thiouracil with hydrazonoyl halides yielded regioselectively 7-amino-1,3-disubstituted-1,2,4-triazolo4,3-a]pyrimidine derivatives. Upon treatment with methyl (Z)-2-benzoylamino-3-dimethylaminopropenoate, the corresponding methyl (Z)-2-benzoylamino-3-(1,2, 4]triazolo4,3-a]pyrimidin-7-yl)-amino propenoates were obtained which cyclized in the presence of sodium ethoxide to afford novel derivatives
of pyrido2,3-d]1,2,4]triazolo4,3-a]pyrimidine-5,6-(1H,8H)-diones.
E-mail: mosselhi@chem-sci.cairo.eun.eg
Received February 8, 2002; accepted (revised) March 18, 2002 |
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| Keywords: | , ,Pyrimidines, Synthetic methods, 1,2,4-Triazolopyrimidinone, Propenoate ester, Pyrido-1,2,4-triazolo-pyrimidinedione |
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