Synthese von (5,10)-(7,8)-Bisepoxiden aus α- und β-4-Phenyl-1,2,4-triazolin-3,5-dion-Addukten von Vitamin D3 und Röntgenstrukturanalyse eines der Benzoylderivate |
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| Authors: | Christof Kratky Wolfgang Reischl Elisabeth Altmann Erich Zbiral |
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| Institution: | 1. Institut für Physikalische Chemie, Universit?t Graz, A-1080, Graz, ?sterreich
2. Institut für Organische Chemie, Universit?t Wien, A-1090, Wien, ?sterreich
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| Abstract: | Oxidation of the α- and β-4-phenyl-1,2,4-triazolin-3,5-dione adducts of vitamin D3 (2 and1) withMCPBA yields two diastereomeric mixtures of the (5,10)-(7,8)-dioxiranes3 a,3 b,3 c and4 a,4 b respectively. The corresponding benzoates5 a,5 b,6 a and6 b were prepared and the X-ray crystal structure of5 b was determined. This analysis proved5 b to be the (5R, 1 OS)-(7R, 8R)-dioxirane of the β-resp. (6S)-4-phenyl-1,2,4-triazolin-3,5-dione adduct1 of vitamin D3. |
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