|
|||||
|
|
Calculation of cyclodextrin-mediated enantiomer ratio shifting of racem norgestrel in aqueous solutions |
|
| Authors: | Dávid Szegvári Romána Zelkó Péter Horváth András Gergely |
| Institution: | (1) Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. Street 9, H-1092 Budapest, Hungary;(2) University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Street 9, H-1092 Budapest, Hungary |
| Abstract: | Enantioselective solubility of rac-norgestrel was found in the presence of γ-cyclodextrin or hydroxypropyl-γ-cyclodextrin. In both cases the efficacious enantiomer was dissolved in greater extent. Calculating the molar absorptivity and molar ellipticity spectra of the γ- and hydroxypropyl-γ-cyclodextrin aqueous complexes, a simple and rapid direct circular dichroism (CD) spectrometric method was obtained for the determination of the enantiomer ratio in aqueous solutions. |
| Keywords: | Enantioselective solubility Circular dichroism γ -cyclodextrin HP-γ -cyclodextrin Inclusion complexes Molar absorptivity Molar ellipticity Norgestrel |
| 本文献已被 SpringerLink 等数据库收录！ | |