Formulation of betacyclodextrin based nanosponges of itraconazole |
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Authors: | Shankar Swaminathan P R Vavia Francesco Trotta Satyen Torne |
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Institution: | (1) Pharmaceutical Division, Mumbai University Institute of Chemical Technology, Matunga, Mumbai, 400019, India;(2) Departimento di Chemica IFM, Universita degli studi di Torino, Via Pietro Giuria 7, Torino, 10125, Italy |
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Abstract: | Nanosponges are betacyclodextrins crosslinked with carbonate bonds. The polymer formed is nanoparticulate in nature. Itraconazole
is a BCS Class II drug that has a dissolution rate limited poor bioavailability. Rationale of the work was to enhance the
solubility of Itraconazole so that the bioavailability problems are solved. Solid dispersion technique has been used for drug
incorporation. The effect of a ternary component copolyvidonum on solubility of itraconazole has been studied. Phase solubility
studies has been carried out with a rationale of comparing the solubilization efficiency of nanosponges, copolyvidonum and
combination. The dispersions were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD)
and photon correlation spectroscopy (PCS). It was found that the solubility of itraconazole was enhanced more than 50-folds
with a ternary solid dispersion system. Using copolyvidonum in conjunction with nanosponges helps to increase the solubilization
efficiency of nanosponges as evident from the phase solubility studies. |
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Keywords: | Betacyclodextrins Nanosponges Itraconazole |
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