Novel pyrrolo-quinazolino-quinoline analogues of the natural alkaloids and their inclusion molecular complexes in the native cyclodextrins: experimental versus theoretical study

A series ten novel analogs based on a novel template pyrrolo-quinazolino-quinolines, containing Luotonin-A (Luot-A) and 14-aza-camptothecin (14-aza-CPT) molecular core as well as their inclusion complexes in the native α- (α-CD), β- (β-CD) and γ- (β-CD) cyclodextrins were obtained. The physical properties of the alkaloids and corresponding molecular complexes with cyclodextrins are elucidated experimentally by the electronic absorption and CD-spectroscopy, electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry and nuclear magnetic resonance method. The experimental data are supported by the theoretical quantum chemical calculations of the molecular and electronic structures as well as physical properties in condense phase.