Spectroscopic investigation of Rose Bengal/cyclodextrin interactions in aqueous solution: the case of the hydroxypropyl-cyclodextrins |
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| Authors: | P Fini L Catucci M Castagnolo P Cosma V Pluchinotta A Agostiano |
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| Institution: | (1) Istituto per i Processi Chimico Fisici (IPCF) CNR, sez. Bari, Via Orabona 4, Bari, 70126, Italy;(2) Dipartimento di Chimica, Universita’ di Bari, Via Orabona 4, Bari, 70126, Italy |
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| Abstract: | The interaction of Rose Bengal (RB) with hydroxypropyl-α-cyclodextrin (HP-α-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD) and
hydroxypropyl-γ-cyclodextrin (HP-γ-CD) has been studied in water and in acetate buffer at pH 4.5 by UV–Vis absorption, fluorescence
spectroscopy and Induced Circular Dichroism at 298 K. Evidence of the complex formation between the RB and all HP-CDs have
been obtained both in water and in buffer. Binding constants and stoichiometry of RB/HP-CD complexes in water have been determined
by applying the modified Benesi-Hildebrand equation to the fluorescence measurements. |
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| Keywords: | Rose Bengal Aqueous solutions Hydroxypropyl-Cyclodextrins Inclusion complexes pH |
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