Interaction of DNA oligomers with cationic lipidic monolayers: complexation and splitting |
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Authors: | Erokhina Svetlana Berzina Tatiana Cristofolini Luigi Konovalov Oleg Erokhin Victor Fontana Marco P |
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Institution: | Department of Physics, University of Parma, Viale Usberti 7 A, 43100 Parma, Italy. erokhin@fis.unipr.it |
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Abstract: | Interactions of native DNA with octadecylamine (ODA) and hexadecymdimethylammonium bromide (HTAB) monolayers at the air/water interface were studied by pi-A isotherms, ellipsometry, and X-ray reflectivity. We show that the microscopic structure of ODA-DNA complexes is definitely consistent with a single-stranded form for DNA. On the contrary, with HTAB, DNA complexes in its native form. The crucial difference in the behavior of these two fairly similar lipids is due to the presence of the amine group in ODA. These results should be relevant to applications such as DNA chips and sensors. |
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