| 2-(4-氨酰基-2-噻唑基)-1,4-脱水-L-木糖醇及其氟代衍生物的构象研究 |
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| 引用本文： | 张虎翼,张亮仁,马灵台,张礼和,崔育新,刘雪辉.2-(4-氨酰基-2-噻唑基)-1,4-脱水-L-木糖醇及其氟代衍生物的构象研究[J].高等学校化学学报,1998,19(11):1767-1770. |
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| 作者姓名： | 张虎翼 张亮仁 马灵台 张礼和 崔育新 刘雪辉 |
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| 作者单位： | 1. 北京医科大学药学院抗肿瘤药物研究室, 北京, 100083;
2. 北京医科大学药学院抗肿瘤药物研究室, 天然药物及仿生药物国家重点实验室, 北京, 100083 |
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| 摘 要： | 用计算机分子模拟方法研究了2-(4-氨酰基-2-噻唑基)-1,4-脱水-L-木糖醇及其氟代衍生物的糖基构象.计算结果显示,6个碳核苷类似物的糖基构象均为S型.核磁共振谱和晶体x射线衍射结果与计算结果相吻合.
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| 关 键 词： | 构象 计算机分子模拟 核磁共振 晶体X射线分析 异碳核苷 |
| 收稿时间： | 1997-12-13 |
| 修稿时间： | 1997年12月13日 |
Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives |
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| ZHANG Hu-Yi,ZHANG Liang-Ren,MA Ling-Tai,ZHANG Li-He,CUI Yu-Xin,LIU Xue-Hui.Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives[J].Chemical Research In Chinese Universities,1998,19(11):1767-1770. |
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| Authors: | ZHANG Hu-Yi ZHANG Liang-Ren MA Ling-Tai ZHANG Li-He CUI Yu-Xin LIU Xue-Hui |
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| Institution: | 1. Research Group of Antitumor Drugs, School of Phamaceutical Sciences;
2. National Research Laboratory of Natural and Biommetic Drugs, Beijing Medical University, Beijing, 100083 |
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| Abstract: | Employing computer aided molecule simulation, the conformations of 2 (4 aminocarbonyl 2 thiazoyl) 1,4 anhydro L xylitols and their fluorine derivatives have been studied. The results obtained from calculation show that these novel isomeric C nucleosides favor the S conformation. NMR study and crystal X ray analysis of these compounds coincidentally point to S type furanose conformation. |
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| Keywords: | Conformation Computer aided molecule simulation NMR Crystal X ray analysis iso C nuleosides |
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