| 氟尿嘧啶自旋标记衍生物的合成与抗肿瘤活性 |
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| 引用本文： | 王彦广,田暄,李景新,陈耀祖.氟尿嘧啶自旋标记衍生物的合成与抗肿瘤活性[J].高等学校化学学报,1993,14(10):1399. |
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| 作者姓名： | 王彦广 田暄 李景新 陈耀祖 |
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| 作者单位： | 1. 天津大学化学系, 天津 300072;
2. 兰州大学化学系 |
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| 摘 要： | 稳定氮氧自由基作为某些抗癌药物的载体,不仅能提高药物对癌细胞的选择性,而且为借助电子自旋共振(ESR)技术研究药物的作用机理和代谢提供了一种新手段。在前文中,我们报道了几种5-氟尿嘧啶的自旋标记衍生物。作为这一工作的继续,本文报道一系列新的氟尿嘧啶自旋标记衍生物10_(a—c)、11_(a—c)和12_(a—c)的合成及其抗肿瘤活性的研究。
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| 关 键 词： | 氟尿嘧啶 自旋标记 抗肿瘤活性 合成 |
| 收稿时间： | 1993-11-19 |
Syntheses and Antitumor Activities of New Spin-labeled 5-Fluorouracil Derivatives |
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| WANG Yan-Guang TIAN Xuan,LI Jing-Xin,CHEN Yao-Zu.Syntheses and Antitumor Activities of New Spin-labeled 5-Fluorouracil Derivatives[J].Chemical Research In Chinese Universities,1993,14(10):1399. |
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| Authors: | WANG Yan-Guang TIAN Xuan LI Jing-Xin CHEN Yao-Zu |
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| Institution: | 1. Chem.Dept., Tianjin University, Tianjin, 300072;
2. Chem.Dept., Lanzhou University |
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| Abstract: | A series of new spin-labeled 5-fluorouracil derivatives, as potential antitumor agents, were synthesized, and their structures were confirmed by IR, UV, MS and ESR spectra as well as elemental analysis. The antitumor activities of these compounds were tested against EAC in mice. The preliminary results showed that some of the compounds exhibit certain antitumor activity. |
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| Keywords: | Fluorouracil Spin labeling Antitumor activity Synthesis (Ed : J H A) |
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