| Gd(DTPA-BIN)与人血清白蛋白作用的核磁共振研究 |
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| 引用本文： | 李欣宇,张善荣,景凤英,吴亦洁,裴奉奎.Gd(DTPA-BIN)与人血清白蛋白作用的核磁共振研究[J].高等学校化学学报,1998,19(12):2026-2028. |
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| 作者姓名： | 李欣宇 张善荣 景凤英 吴亦洁 裴奉奎 |
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| 作者单位： | 中国科学院长春应用化学研究所应用谱学开放实验室, 长春, 130022 |
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| 基金项目： | 中国科学院“九五”预研基金 |
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| 摘 要： | 造影剂通常为Ｇｄ３＋、Ｍｎ２＋或Ｆｅ３＋的稳定化合物．它们能改变体内水分子氢核的弛豫速率，从而提高正常与病变组织的磁共振成像（ＭａｇｎｅｔｉｃＲｅｓｏｎａｎｃｅＩｍａｇｉｎｇ，ＭＲＩ）对比度或显示体内器官的功能状态．因此，开发新优ＭＲＩ造影剂具有重要...
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| 关 键 词： | Gd(DTPA-BIN) 人血清白蛋白 弛豫分析 |
| 收稿时间： | 1997-11-27 |
| 修稿时间： | 1997年11月27日 |
NMR Studies of Gd(DTPA-BIN)in Human Serum Albumin Solution |
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| LI Xin-Yu,ZHANG Shan-Rong,JING Feng-Ying,WU Yi-Jie,PEI Feng-Kui.NMR Studies of Gd(DTPA-BIN)in Human Serum Albumin Solution[J].Chemical Research In Chinese Universities,1998,19(12):2026-2028. |
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| Authors: | LI Xin-Yu ZHANG Shan-Rong JING Feng-Ying WU Yi-Jie PEI Feng-Kui |
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| Institution: | The Key Laboratory of Applied Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 |
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| Abstract: | Stable gadolinium complexes, such as Gd(DTPA) and Gd(DOTA), are usually used as the contrast agents for magnetic resonance imaging(MRI). Reported here are the enhanced relaxation properties of a novel gadolinium complex, diethylene triaminopentaacetate bis(isoniazid) Gd(DTPA BIN) , in aqueous and in human serum albumin(HSA) solution, which indicates that (1) two Gd(DTPA BIN) can integrate non covalently with one HSA with an equilibrium constant of 0.02 mmol -2 \5L 2; (2) the relaxivities are 3.28 and 4.92 mmol -1 \5L\5s -1 for the free Gd(DTPA BIN) and the Gd(DTPA BIN) 2 HSA conjugator, respectively; (3) the rotational correlation time of protein conjugator is notably higher than that of the free complex. The above results may imply that Gd(DTPA BIN) has a higher tissue selectivity than that of its parent Gd(DTPA). |
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| Keywords: | Gd (DTPA BIN) Human serum albumin Relaxation analysis |
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