| 1a,3-二苯基-1,1,4,4-四氯-1a,2,3,4-四氢-1H-吖丙啶并[2,1-e][1,6]苯并硫氮杂辛因的合成及晶体结构 |
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| 引用本文： | 许家喜,兰若曦,金声.1a,3-二苯基-1,1,4,4-四氯-1a,2,3,4-四氢-1H-吖丙啶并[2,1-e][1,6]苯并硫氮杂辛因的合成及晶体结构[J].高等学校化学学报,1998,19(11):1774-1776. |
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| 作者姓名： | 许家喜 兰若曦 金声 |
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| 作者单位： | 北京大学化学与分子工程学院, 北京, 100871 |
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| 摘 要： | 苯并杂类化合物为常用镇静剂及治疗心血管疾病和抗病毒的药物［１～３］，苯并杂与五六元杂环并合形成的三环化合物也是重要的药用杂环化合物，如１，４－苯并二氮杂与１，２，４－三唑并合形成的三环化合物为常用的治疗中枢神经系统疾病药物［４］．而吖丙啶与１，...
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| 关 键 词： | 1a 2 3 4-四氢-1H-吖丙啶并[2 1-e][1 6]苯并硫氮杂辛因 晶体结构 分子结构 |
| 收稿时间： | 1998-02-19 |
| 修稿时间： | 1998年2月19日 |
Synthesis and Crystal Structure of 1,1,4,4-Tetrachloro-1a,3-diphenyl-1a,2,3,4-tetrahydro-1H-Azirino[2,1-e][1,6]benzothiazocine |
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| XU Jia-Xi,LAN Ruo-Xi,JIN Sheng.Synthesis and Crystal Structure of 1,1,4,4-Tetrachloro-1a,3-diphenyl-1a,2,3,4-tetrahydro-1H-Azirino[2,1-e][1,6]benzothiazocine[J].Chemical Research In Chinese Universities,1998,19(11):1774-1776. |
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| Authors: | XU Jia-Xi LAN Ruo-Xi JIN Sheng |
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| Institution: | College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 |
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| Abstract: | Title compound was synthesized by insertion and cycloaddition reaction of 2,4-diphenyl-2,3-dihydro-1,5-benzothiazepine and dichlorocarbene generated from chloroform under the alkaline condition and its crystal structure was determined by X-ray diffraction method. The single crystals belong to orthogonal, space group Pc21 /n with a = 1.0243(2) nm, b = 1.1451(2) nm, c = 1.8388(3) nm, V = 2. 1570(5) nm3, Z =4, Dc=1.693 g·cm-3, μ =0.066 mm-1, F (000)= 1066 for 2467 reflections, R =0.039, Rw=0.054. |
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| Keywords: | a 2 3 4 Tetrahydro 1H azirinobenzothiazocine Crystal structure Molecular structure |
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