不同磺化及碱处理聚醚醚酮的表面化学组成及体外生物活性评价

提出一种酸碱结合改性聚醚醚酮（PEEK）方法，并评价其对PEEK表面类骨磷灰石形成的影响.结果表明，通过磺化处理引入-SO₃H，显著改善了样品的亲水性，且磺化程度与H₂SO₄浓度和磺化反应时间成正比，并影响样品的表面形貌.质量分数为85% H₂SO₄处理30 min的PEEK-S具有较好的改性效果.将PEEK-S进一步用NaOH处理，可继续引入Na元素并提高样品的亲水性，但会受处理时间的影响.模拟体液（SBF）浸泡的生物活性评价结果表明，磺化后碱处理24 h的PEEK-Na具有快速的类骨磷灰石沉积能力，浸泡3 d的样品表面即可完全被沉积的类骨磷灰石覆盖，表现出较佳的生物活性.此酸碱双重改性方法操作简单，可大幅度提升PEEK的生物活性，具有较好的应用前景.

Surface Elemental Compositions and in Vitro Bioactivities of the PEEK Materials with Various Sulfonation and Alkali Treatments

A novel method combining sulfonation with alkali treatment for the surface chemical modification of polyetheretherketone(PEEK) was proposed and developed to endow PEEK with significantly enhanced bioactivity. The modified PEEK samples were subjected to the in vitro evaluation on the formation of bone-like apatite. The results showed that the sulfonation treatment improved the hydrophilicity of PEEK by introducing -SO₃H into the surface, and the sulfonation degree and surface morphology of the PEEK samples were influenced by the H₂SO₄ concentration and reactive time. PEEK-S(85%H₂SO₄, 30 min) presented better modification effect than other PEKK-S samples. The NaOH treatment for PEEK-S(85%H₂SO₄, 30 min) introduced Na into the surface and further increased its hydrophilicity, as was also affected by the reactive time. The in vitro bioactivity evaluation via simulated body fluid(SBF) immersion confirmed that the sulfonated PEEK samples treated with NaOH solution, i. e. PEEK-Na had rapid speed to form bone-like apatite on the surface. Only 3 d of soaking in SBF, PEEK-Na(24 h) was fully covered by a layer of bone-like apatite, showing good bioactivity. The current modification method is simple and thus promising for practical applications to improve the bioactivity of PEEK materials.