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脂质响应型探针用于动脉粥样硬化成像及治疗的研究进展
引用本文:徐心昱,张乐天,曹晖,马原,刘柳卉,宋国胜,张晓兵.脂质响应型探针用于动脉粥样硬化成像及治疗的研究进展[J].高等学校化学学报,2022,43(12):20220383.
作者姓名:徐心昱  张乐天  曹晖  马原  刘柳卉  宋国胜  张晓兵
作者单位:湖南大学化学化工学院, 化学生物传感与计量学国家重点实验室, 长沙 410082
基金项目:国家重点研发计划项目(2019YFA0210100);国家自然科学基金(21890744);湖南省科技专项基金(2020RC3022)
摘    要:动脉粥样硬化是心血管疾病的主要威胁之一, 可能导致如急性心肌梗死在内的急性冠状动脉综合征、 卒中, 甚至猝死等一系列严重的不良后果. 脂质的异常积累是动脉粥样硬化的标志之一, 有必要观察它们在体内的数量、 定位和分布. 荧光探针具有可操作性强、 高时空分辨率和与活体生物相容性佳的优点, 有望成为了解动脉粥样硬化中的脂质功能的有利工具. 本文综合评述了基于罗丹明、 香豆素、 氟化硼二吡咯(BODIPY)、 1,8-萘酰亚胺等有机框架结构以及金属配合物的脂滴特异性光学成像探针的研究进展, 并重点介绍了其在动脉粥样硬化斑块成像、 手术导航及治疗等领域的应用. 最后, 对该研究领域进行了总结和展望, 希望可为相关研究提供有益参考.

关 键 词:荧光探针  脂滴成像  动脉粥样硬化  
收稿时间:2022-05-30

Recent Advances in Lipid-responsive Probes in the Imaging and Treatment of Atherosclerosis
XU Xinyu,ZHANG Letian,CAO Hui,MA Yuan,LIU Liuhui,SONG Guosheng,ZHANG Xiaobing.Recent Advances in Lipid-responsive Probes in the Imaging and Treatment of Atherosclerosis[J].Chemical Research In Chinese Universities,2022,43(12):20220383.
Authors:XU Xinyu  ZHANG Letian  CAO Hui  MA Yuan  LIU Liuhui  SONG Guosheng  ZHANG Xiaobing
Institution:State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China
Abstract:Atherosclerosis(AS) is one of the main threats of cardiovascular diseases(CVDs) and may lead to a series of serious adverse consequences such as acute coronary syndromes(e.g., acute myocardial infarction), stroke, and even sudden death. Abnormal accumulation of lipids is one of the signatures of AS, and it is necessary to observe their quantity, localization, and distribution in vivo. Fluorescent probes with the advantages of high operability, high spatial and temporal resolution, and good biocompatibility are expected to be favorable tools for understanding lipid function in AS. This review summarizes lipid droplet(LD)-specific optical imaging probes based on organic framework structures such as rhodamine, coumarin, dipyrromethene boron difluoride(BODIPY), 1,8-naphthalimide, and metal complex probes, and highlights their applications in atherosclerotic plaque imaging, imaging-guided surgery and therapy. Finally, a summary and outlook on the field are presented, hoping to provide useful references for related research.
Keywords:Fluorescent probe  Lipid droplet imaging  Atherosclerosis  
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