可见光诱导邻烯基甲酰苯胺环化合成2-喹啉酮

使用廉价易得的邻烯基甲酰苯胺在可见光的诱导下发生自由基环化反应, 以良好至优秀的产率合成了15种2-喹啉酮衍生物. 该方法简单高效、 条件温和、 产率较高, 具有优异的官能团兼容性, 不仅拓展了邻烯基甲酰苯胺参与的新型有机反应, 也为光催化合成喹啉酮类化合物提供了一条新途径.

Visible Light Induced Cyclization of O-Alkenylcarboxanilide to 2-Quinolinone

A free radical cyclization reaction induced by visible light using cheap and readily available O-alkenylformanilide was developed. The strategy was used to synthesize fifteen 2-quinolinone derivatives in good to excellent yields. This method is simple and efficient， with mild conditions and excellent functional group compatibility. Meanwhile， a plausible mechanism is proposed on the basis of several mechanistic experiments and literature precedents. This method not only provides a new type of organic reaction involving O-alkenylformylanilide， but also provides a new pathway for the photocatalytic synthesis of quinolinones.